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1

CYP2A6: genetics, structure, regulation, and function

Raunio, Hannu, Rahnasto-Rilla, Minna

Journal:

Drug Metabolism and Drug Interactions

Année:

2012

Langue:

english

Fichier:

PDF, 621 KB

english, 2012

2

Expression of CYP1A1, CYP1B1 and CYP3A, and polycyclic aromatic hydrocarbon-DNA adduct formation in bronchoalveolar macrophages of smokers and non-smokers

Ritva Piipari, Kirsti Savela, Tuula Nurminen, Janne Hukkanen, Hannu Raunio, Jukka Hakkola, Timo Mäntylä, Philippe Beaune, Robert J. Edwards, Alan R. Boobis, Sisko Anttila

Journal:

International Journal of Cancer

Année:

2000

Langue:

english

Fichier:

PDF, 107 KB

english, 2000

3

Expression of CYP2A genes in human liver and extrahepatic tissues

Satu Koskela, Jukka Hakkola, Janne Hukkanen, Olavi Pelkonen, Martti Sorri, Antti Saranen, Sisko Anttila, Pedro Fernandez-Salguero, Frank Gonzalez, Hannu Raunio

Journal:

Biochemical Pharmacology

Année:

1999

Langue:

english

Fichier:

PDF, 260 KB

english, 1999

4

Expression of xenobiotic-metabolizing cytochrome P450 forms in human adult and fetal liver

Jukka Hakkola, Markku Pasanen, Raija Purkunen, Seppo Saarikoski, Olavi Pelkonen, Jukka Mäenpää, Anders Rane, Hannu Raunio

Journal:

Biochemical Pharmacology

Année:

1994

Langue:

english

Fichier:

PDF, 624 KB

english, 1994

5

Expression and Regulation of Xenobiotic-Metabolizing Cytochrome P450 (CYP) Enzymes in Human Lung

Hukkanen, Janne, Pelkonen, Olavi, Hakkola, Jukka, Raunio, Hannu

Journal:

Critical Reviews in Toxicology

Année:

2002

Langue:

english

Fichier:

PDF, 262 KB

english, 2002

6

Ultrafast protein structure-based virtual screening with Panther

Niinivehmas, Sanna P., Salokas, Kari, Lätti, Sakari, Raunio, Hannu, Pentikäinen, Olli T.

Journal:

Journal of Computer-Aided Molecular Design

Année:

2015

Langue:

english

Fichier:

PDF, 1.43 MB

english, 2015

7

Function and Regulation of the Cyp2a5/CYP2A6 Genes in Response to Toxic Insults in the Liver

Abu-Bakar, A'edah, Hakkola, Jukka, Juvonen, Risto, Rahnasto-Rilla, Minna, Raunio, Hannu, A. Lang, Matti

Journal:

Current Drug Metabolism

Année:

2013

Langue:

english

Fichier:

PDF, 670 KB

english, 2013

8

Detection of mRNA encoding xenobiotic-metabolizing cytochrome P450s in human bronchoalveolar macrophages and peripheral blood lymphocytes

Janne Hukkanen, Jukka Hakkola, Sisko Anttila, Ritva Piipari, Antti Karjalainen, Olavi Pelkonen, Hannu Raunio

Journal:

Molecular Carcinogenesis

Année:

1997

Langue:

english

Fichier:

PDF, 164 KB

english, 1997

9

Cytochrome P4502A6 (CYP2A6) expression in human hepatocellular carcinoma

Hannu Raunio, Risto Juvonen, Markku Pasanen, Olavi Pelkonen, Paavo Pääkkö, Ylermi Soini

Journal:

Année:

1998

Langue:

english

Fichier:

PDF, 144 KB

english, 1998

10

Comparison of the formation of benzo[a]pyrene diolepoxide-dna adducts in vitro by rat and human microsomes: Evidence for the involvement of p-450IA1 and p-450IA2

Dr Kirsi Vähäkangas, Hannu Raunio, Markku Pasamen, Päivi Sivonen, Sang-Shin Park, Harry V. Gelboin, Olavi Pelkonen

Journal:

Journal of Biochemical and Molecular Toxicology

Année:

1989

Langue:

english

Fichier:

PDF, 632 KB

english, 1989

11

Immunochemical and molecular biological studies on human placental cigarette smoke-inducible cytochrome P-450-dependent monooxygenase activities

Markku Pasanen, Tapio Haaparanta, Maria Sundin, Paivi Sivonen, Kirsi Vakakangas, Hannu Raunio, Ronald Hines, Jan-Åk Gustafsson, Olavi Pelkonen

Journal:

Année:

1990

Langue:

english

Fichier:

PDF, 883 KB

english, 1990

12

CYP2A6: a human coumarin 7-hydroxylase

Olavi Pelkonen, Arja Rautio, Hannu Raunio, Markku Pasanen

Journal:

Année:

2000

Langue:

english

Fichier:

PDF, 85 KB

english, 2000

13

Polymorphisms of CYP2A6 and its practical consequences

Hannu Raunio, Arja Rautio, Harriet Gullstén, Olavi Pelkonen

Journal:

British Journal of Clinical Pharmacology

Année:

2001

Langue:

english

Fichier:

PDF, 128 KB

english, 2001

14

Expression of cytochrome P 450 3A enzymes in human lung: a combined RT-PCR and immunohistochemical analysis of normal tissue and lung tumours

Kari T. Kivistö, Ernst-Ulrich Griese, Peter Fritz, Albert Linder, Jukka Hakkola, Hannu Raunio, Philippe Beaune, Heyo K. Kroemer

Journal:

Naunyn-Schmiedeberg's Archives of Pharmacology

Année:

1996

Langue:

english

Fichier:

PDF, 715 KB

english, 1996

15

Regulation of CYP2A5 induction by porphyrinogenic agents in mouse primary hepatocytes

P. Salonpää, Sami Kottari, Olavi Pelkonen, Hannu Raunio

Journal:

Naunyn-Schmiedeberg's Archives of Pharmacology

Année:

1996

Langue:

english

Fichier:

PDF, 239 KB

english, 1996

16

Inhibition and induction of human cytochrome P450 enzymes: current status

Olavi Pelkonen, Miia Turpeinen, Jukka Hakkola, Paavo Honkakoski, Janne Hukkanen, Hannu Raunio

Journal:

Archives of Toxicology

Année:

2008

Langue:

english

Fichier:

PDF, 790 KB

english, 2008

17

The role of CYP enzymes in cocaine-induced liver damage

Markku Pasanen, Pertti Pellinen, Frej Stenbäck, Risto O. Juvonen, Hannu Raunio, Olavi Pelkonen

Journal:

Archives of Toxicology

Année:

1995

Langue:

english

Fichier:

PDF, 408 KB

english, 1995

18

Induction of CYP2A5 by pyrazole and its derivatives in mouse primary hepatocytes

Anneli Kojo, Pirkko Viitala, Markku Pasanen, Olavi Pelkonen, Hannu Raunio, Risto Juvonen

Journal:

Archives of Toxicology

Année:

1998

Langue:

english

Fichier:

PDF, 326 KB

english, 1998

19

Use of an online surveillance system for screening drug interactions in prescriptions in community pharmacies

Tiina Heikkilä, Tuula Lekander, Hannu Raunio

Journal:

European Journal of Clinical Pharmacology

Année:

2006

Langue:

english

Fichier:

PDF, 94 KB

english, 2006

20

Novel Cyclic Phosphate Prodrug Approach for Cytochrome P450-activated Drugs Containing an Alcohol Functionality

Kristiina M. Huttunen, Niina Mähönen, Jukka Leppänen, Jouko Vepsäläinen, Risto O. Juvonen, Hannu Raunio, Hanna Kumpulainen, Tomi Järvinen, Jarkko Rautio

Journal:

Pharmaceutical Research

Année:

2007

Langue:

english

Fichier:

PDF, 344 KB

english, 2007

21

Expression of Cytochrome P450 Genes Encoding Enzymes Active in the Metabolism of Tamoxifen in Human Uterine Endometrium

Janne Hukkanen, Marjatta Mantyla, Lauri Kangas, Pauli Wirta, Jukka Hakkola, Pauliina Paakki, Sari Evisalmi, Olavi Pelkonen, Hannu Raunio

Journal:

Basic & Clinical Pharmacology & Toxicology

Année:

1998

Langue:

english

Fichier:

PDF, 527 KB

english, 1998

22

Expression of CYP2E1 in Human Lung and Kidney during Development and in Full-Term Placenta: A Differential Methylation of the Gene is Involved in the Regulation Process

Isabel Vieira, Markku Pasanen, Hannu Raunio, Thierry Cresteil

Journal:

Basic & Clinical Pharmacology & Toxicology

Année:

1998

Langue:

english

Fichier:

PDF, 561 KB

english, 1998

23

Prediction of Drug Metabolism and Interactions on the Basis of in vitro Investigations

Olavi Pelkonen, Miia Turpeinen, Jouko Uusitalo, Arja Rautio, Hannu Raunio

Journal:

Basic & Clinical Pharmacology & Toxicology

Année:

2005

Langue:

english

Fichier:

PDF, 90 KB

english, 2005

24

Independent Induction and Inhibition of Ornithine Decarboxylase and Aryl Hydrocarbon Hydroxylase Activities in Rat Epidermis.

Raunio, Hannu, Pelkonen, Olavi

Journal:

The Journal of Investigative Dermatology

Année:

1982

Fichier:

PDF, 2.25 MB

1982

25

The expression of cytochrome P450 enzymes in human breast tumours and normal breast tissue

Mumtaz Iscan, Tuula Klaavuniemi, Tulay Çoban, Nilgun Kapucuoğlu, Olavi Pelkonen, Hannu Raunio

Journal:

Breast Cancer Research and Treatment

Année:

2001

Langue:

english

Fichier:

PDF, 181 KB

english, 2001

26

Accelerated apoptosis and low Bcl-2 expression associated with neuroendocrine differentiation predict shortened survival in operated large cell carcinoma of the lung

Anna-Kaisa Eerola, Henni Ruokolainen, Ylermi Soini, Hannu Raunio, Paavo PÄÄKKÖ

Journal:

Pathology & Oncology Research

Année:

1999

Langue:

english

Fichier:

PDF, 149 KB

english, 1999

27

Up-regulation of CYP2A5 expression by porphyrinogenic agents in mouse liver

Pirkko Salonpää, Kai Krause, Olavi Pelkonen, Hannu Raunio

Journal:

Naunyn-Schmiedeberg's Archives of Pharmacology

Année:

1995

Langue:

english

Fichier:

PDF, 661 KB

english, 1995

28

Hepatic Ah-receptor levels and the effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on hepatic microsomal monooxygenase activities in a TCDD-susceptible and -resistant rat strain

Raimo Pohjanvirta, Risto Juvonen, Sirpa Kärenlampi, Hannu Raunio, Jouko Tuomisto

Journal:

Toxicology and Applied Pharmacology

Année:

1988

Langue:

english

Fichier:

PDF, 873 KB

english, 1988

29

Cytochrome P450 isozyme induction by methyl ethyl ketone and m-xylene in rat liver

Hannu Raunio, Juha Liira, Eivor Elovaara, Vesa Riihimäki, Olavi Pelkonen

Journal:

Toxicology and Applied Pharmacology

Année:

1990

Langue:

english

Fichier:

PDF, 729 KB

english, 1990

30

Comparison of the immunochemical properties of human placental and bovine adrenal cholesterol side-chain cleavage enzyme complex

Sergei A. Usanov, Paavo Honkakoski, Matti A. Lang, Markku Pasanen, Olavi Pelkonen, Hannu Raunio

Journal:

Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology

Année:

1989

Langue:

english

Fichier:

PDF, 1.04 MB

english, 1989

31

Identification of novel CYP2A6 inhibitors by virtual screening

Minna K. Rahnasto, Hannu A. Raunio, Carsten Wittekindt, Kaisa A. Salminen, Jukka Leppänen, Risto O. Juvonen, Antti Poso, Maija K. Lahtela-Kakkonen

Journal:

Bioorganic & Medicinal Chemistry

Année:

2011

Langue:

english

Fichier:

PDF, 710 KB

english, 2011

32

Regulation of CYP3A genes in the human respiratory tract

Hannu Raunio, Jukka Hakkola, Olavi Pelkonen

Journal:

Chemico-Biological Interactions

Année:

2005

Langue:

english

Fichier:

PDF, 310 KB

english, 2005

33

Antifungal activities of novel non-azole molecules against S. cerevisiae and C. albicans

Niina Tani, Minna Rahnasto-Rilla, Carsten Wittekindt, Kaisa A. Salminen, Anniina Ritvanen, Riina Ollakka, Jenna Koskiranta, Hannu Raunio, Risto O. Juvonen

Journal:

European Journal of Medicinal Chemistry

Année:

2012

Langue:

english

Fichier:

PDF, 1.09 MB

english, 2012

34

Inhibition of human drug metabolizing cytochrome P450 enzymes by plant isoquinoline alkaloids

Kaisa A. Salminen, Achim Meyer, Lenka Jerabkova, Laura E. Korhonen, Minna Rahnasto, Risto O. Juvonen, Peter Imming, Hannu Raunio

Journal:

Année:

2011

Langue:

english

Fichier:

PDF, 192 KB

english, 2011

35

Metabolism of bilirubin by human cytochrome P450 2A6

A'edah Abu-Bakar, Dionne M. Arthur, Anna S. Wikman, Minna Rahnasto, Risto O. Juvonen, Jouko Vepsäläinen, Hannu Raunio, Jack C. Ng, Matti A. Lang

Journal:

Toxicology and Applied Pharmacology

Année:

2012

Langue:

english

Fichier:

PDF, 940 KB

english, 2012

36

Lack of association between CYP2A5 induction and apoptosis in mouse primary hepatocytes

Sami Tetri, Minna Ruhanen, Pirkko Viitala, Olavi Pelkonen, Markku Pasanen, Hannu Raunio

Journal:

Biochemical Pharmacology

Année:

2002

Langue:

english

Fichier:

PDF, 373 KB

english, 2002

37

Modulation of murine phenobarbital-inducible CYP2A5, CYP2B10 and CYP1A enzymes by inhibitors of protein kinases and phosphatases

Katja Posti, Susanna Leinonen, Sami Tetri, Sami Kottari, Pirkko Viitala, Olavi Pelkonen, Hannu Raunio

Journal:

Année:

1999

Langue:

english

Fichier:

PDF, 664 KB

english, 1999

38

Effects of Cigarette Smoke on Rat Lung and Liver Ornithine Decarboxylase and Aryl Hydrocarbon Hydroxylase Activities and Lung Benzo(a)pyrene Metabolism

Hannu Raunio, Kirsi Vähäkangas, Hannu Saarni, Olavi Pelkonen

Journal:

Basic & Clinical Pharmacology & Toxicology

Année:

1983

Langue:

english

Fichier:

PDF, 468 KB

english, 1983

39

Cytochrome P4502A-Mediated Cownarin 7-Hydroxylation and Testosterone Hydroxylation in Mouse and Rat Lung

Paavo Honkakoski, Jukka Mäenpää, Junnu Leikola, Markku Pasanen, Risto Juvonen, Matti A. Lang, Olavi Pelkonen, Hannu Raunio

Journal:

Basic & Clinical Pharmacology & Toxicology

Année:

1993

Langue:

english

Fichier:

PDF, 722 KB

english, 1993

40

2-(4′-Chlorophenyl)benzothiazole is a potent inducer of cytochrome P450IA1 in a human and a mouse cell line : Anomalous correlation between protein and mRNA induction

Sirpa O. KÄENLAMPI, Katri TUOMI, Merja KORKALAINEN, Hannu RAUNIO

Journal:

Année:

1989

Langue:

english

Fichier:

PDF, 774 KB

english, 1989

41

Design, Synthesis, and Evaluation of Novel Cyclic Phosphates of 5-Aminosalicylic Acid as Cytochrome P450-Activated Prodrugs

Huttunen, Kristiina M., Tani, Niina, Juvonen, Risto O., Raunio, Hannu, Rautio, Jarkko

Journal:

Molecular Pharmaceutics

Année:

2013

Langue:

english

Fichier:

PDF, 255 KB

english, 2013

42

From known knowns to known unknowns: predicting in vivo drug metabolites

Pelkonen, Olavi, Tolonen, Ari, Korjamo, Timo, Turpeinen, Miia, Raunio, Hannu

Journal:

Année:

2009

Langue:

english

Fichier:

PDF, 802 KB

english, 2009

43

cAMP Mediated Upregulation of CYP2A5 in Mouse Hepatocytes

Pirkko Viitala, Katja Posti, Aija Lindfors, Olavi Pelkonen, Hannu Raunio

Journal:

Biochemical and Biophysical Research Communications

Année:

2001

Langue:

english

Fichier:

PDF, 119 KB

english, 2001

44

Characterization of the Human Dihydropyrimidine Dehydrogenase Gene

Xiaoxiong Wei, Guillermo Elizondo, Andrea Sapone, Howard L. McLeod, Hannu Raunio, Pedro Fernandez-Salguero, Frank J. Gonzalez

Journal:

Année:

1998

Langue:

english

Fichier:

PDF, 1.99 MB

english, 1998

45

Pyrazole is different from acetone and ethanol as an inducer of the polysubstrate monooxygenase system in mice: Evidence that pyrazole-inducible P450Coh is distinct from acetone-lnducible P450ac

Paavo Honkakoski, Seija Autio, Risto Juvonen, Hannu Raunio, Harry V. Gelboin, Sang Shin Park, Olavi Pelkonen, Matti A. Lang

Journal:

Archives of Biochemistry and Biophysics

Année:

1988

Langue:

english

Fichier:

PDF, 1.36 MB

english, 1988

46

Hepatic mitochondrial coumarin 7-hydroxylase: Comparison with the microsomal enzyme

Paavo Honkakoski, Anneli Kojo, Hannu Raunio, Markku Pasanen, Risto Juvonen, Matti A. Lang

Journal:

Archives of Biochemistry and Biophysics

Année:

1988

Langue:

english

Fichier:

PDF, 1.18 MB

english, 1988

47

Mouse liver P450Coh: Genetic regulation of the pyrazole-inducible enzyme and comparison with other P450 isoenzymes

Matti A. Lang, Risto Juvonen, Päivi Järvinen, Paavo Honkakoski, Hannu Raunio

Journal:

Archives of Biochemistry and Biophysics

Année:

1989

Langue:

english

Fichier:

PDF, 909 KB

english, 1989

48

Dissociation between ornithine decarboxylase activity and aryl hydrocarbon hydroxylase induction in cell cultures treated with benz[a]anthracene and inhibitors of ornithine decarboxylase

Hannu Raunio, Mikael Skurnik, Pekka Korhonen, Olavi Pelkonen

Journal:

Biochemical Pharmacology

Année:

1982

Langue:

english

Fichier:

PDF, 515 KB

english, 1982

49

Immunochemical and catalytical studies on hepatic coumarin 7-hydroxylase in man, rat, and mouse

Hannu Raunio, Tuula Syngelmä, Markku Pasanen, Risto Juvonen, Paavo Honkakoski, Matti A. Kairaluoma, Eero Sotaniemi, Matti A. Lang, Olavi Pelkonen

Journal:

Biochemical Pharmacology

Année:

1988

Langue:

english

Fichier:

PDF, 793 KB

english, 1988

50

Mouse hepatic cytochrome p-450 isozyme induction by 1,4-bis[2-(3,5-dichloropyridyloxy)] benzene, pyrazole, and phenobarbital

Hannu Raunio, Anneli Kojo, Risto Juvonen, Paavo Honkakoski, Päivi Järvinen, Matti A. Lang, Kirsi Vähäkangas, Harry V. Gelboin, Sang-Shin Park, Olavi Pelkonen

Journal:

Biochemical Pharmacology

Année:

1988

Langue:

english

Fichier:

PDF, 838 KB

english, 1988